1-Fluoro-4-(methylsulfonyl)-2-(trifluoromethyl)benzene → 4-Chloro-2-[4-(methylsulfonyl)-2-(trifluoromethyl)phenoxy]-benzenepropanoic acid

HRID 910867Notes

Reaction equation

HRID 910867 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[C:12]([F:15])([F:14])[F:13].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][C:25]([OH:27])=[O:26])=[C:19]([OH:28])[CH:18]=1>>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][C:25]([OH:27])=[O:26])=[C:19]([O:28][C:2]2[CH:7]=[CH:6][C:5]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:4][C:3]=2[C:12]([F:15])([F:14])[F:13])[CH:18]=1

Participants

3

Reactant 2

HCID 534159651-Fluoro-4-(methylsulfonyl)-2-(trifluoromethyl)benzeneHCID 673904453-(4-Chloro-2-hydroxyphenyl)propanoic acid

Product 1

HCID 117187604-Chloro-2-[4-(methylsulfonyl)-2-(trifluoromethyl)phenoxy]-benzenepropanoic acid

Procedure

The title compound was prepared by the method of example 3 step viii) using the product from step i) and the product from example 35 step ii).

Sources & evidence

ORD record
ord-1fa588f809f2408a8805bf077b5632f0
Source dataset
uspto-grants-2011_09
Patent number
US08022248B2

Reaction notes

Loading…