Triethylamine → ethyl (2E)-3-(4-chloro-2-nitrophenyl)prop-2-enoate

Participants

Reaction Steps

1-bromo-4-chloro-2-nitrobenzene (5 g), triethylamine (4.42 ml), ethyl acrylate (22.9 ml), palladium (II) acetate (0.048 g) and triphenylphosphine (0.111 g) in DMF (30 ml) was refluxed at 87° C. for 10 h. Toluene was added and the mixture washed with 2M hydrochloric acid and water. The organics were dried and concentrated under reduced pressure to a brown oil which was triturated with isohexane to give a light brown solid. Yield 4.95 g.

Provenance & Evidence