反应详情

A solution of 2-(2-fluoro-4′-trifluoromethylbiphenyl-4-yl)propionic acid (0.2 g, 0.64 mmoles) in methanol (3 ml) is added with 98% sulfuric acid (0.5 g) and refluxed for 2.5 hours. The solvent is removed under vacuum, the residue is taken up with ethyl acetate (5 ml) and washed with a 5% NaHCO3 solution (5 ml), then with water. The solution is dried over Na2SO4 and concentrated under vacuum to afford an oil (0.2 g, 95%).

1. temperaturerefluxed for 2.5 hours
2. customThe solvent is removed under vacuum
3. washwashed with a 5% NaHCO3 solution (5 ml)
4. dry with materialThe solution is dried over Na2SO4
5. concentrationconcentrated under vacuum