反应详情

A solution of 4-bromo-3-fluorobenzyl bromide (12.2 g, 0.03 moles) in ethanol (100 ml) is added with NaCN (2 g, 0.04 moles) and refluxed for 2 hours. The mixture is concentrated under vacuum; the resulting residue is taken up with water, then extracted with ethyl acetate. The organic phase is washed with brine, dried over sodium sulfate and concentrated under vacuum to give a dark oil (10 g), which is subjected to chromatography on a silica gel column (150 g), eluting with hexane:ethyl ether 7:3, to afford the product in the solid form.

1. temperaturerefluxed for 2 hours
2. concentrationThe mixture is concentrated under vacuum
3. extractionextracted with ethyl acetate
4. washThe organic phase is washed with brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated under vacuum