Methyl Salicylate → HCID 86634716, compound

Participants

Reaction Steps

Using the method of Example 3, Step A, methyl 2-hydroxybenzoate (2.88 mg, 18.9 mmol), 60% sodium hydride in mineral oil (757 mg, 18.9 mmol), and 2-chloro-4-nitropyridine (3.00 g, 18.9 mmol) were reacted to provide methyl 2-(2-chloropyridin-4-yloxy)benzoate (3.51 g, 70% yield) as an oil. 1H NMR (CDCl3) δ 8.22 (d, 1H), 8.05 (d, 1H), 7.63 (t, 1H), 7.40 (t, 1H), 7.16 (d, 1H), 6.72-6.74 (m, 1H), 3.77 (s, 1H).

Provenance & Evidence