Potassium Phosphate, Tribasic → HCID 24827114, compound

Participants

Reaction Steps

Using the method of Example 3, Step B, methyl 2-(2-chloropyridin-4-yloxy)benzoate (1.91 g, 7.23 mmol), 4-methylthiazol-2-amine (16.4 mL, 6.57 mmol), potassium phosphate (1.53 g, 7.23 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.105 g, 0.181 mmol) and Pd2(dba)3 (0.150 g, 0.164 mmol) were reacted in toluene (16 mL) and water (5 mL) to provide methyl 2-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)benzoate as yellow solid. 1H NMR (CDCl3) δ 8.16 (d, 1H), 8.01 (dd, 1H), 7.57 (m, 1H), 7.35 (dt, 1H), 7.13 (d, 1H), 6.43 (dd, 1H), 6.29 (d, 1H), 6.21 (dc, 1H), 3.75 (s, 3H), 2.19 (d, 3H); Mass spectrum (esi) m/z=342 (100) (M+H).

Provenance & Evidence