Water → HCID 24825873, compound

Participants

Reaction Steps

Using the method of Example 3, Step B, 4-methylthiazol-2-amine (3.50 mL, 1.40 mmol), 2-chloro-4-(cyclohexyloxy)pyridine (0.326 g, 1.54 mmol), potassium phosphate (0.327 g, 1.54 mmol), tris(dibenzylideneacetone)dipalladium (0) (0.0321 g, 0.0350 mmol) and 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (0.0223 g, 0.0385 mmol) were reacted in toluene (4 mL) and water (1.5 mL) to afford N-(4-(cyclohexyloxy)pyridin-2-yl)-4-methylthiazol-2-amine (0.127 g, 30.7% yield) as white solid. 1H NMR (CDCl3) δ 8.12 (d, 1H), 6.43 (d, 1H), 6.35 (bs, 1H), 6.32 (d, 1H), 4.29 (m, 1H), 2.34 (d, 3H), 1.97 (m, 2H), 1.80 (m, 2H), 1.54 (m, 3H), 1.36 (m, 3H); Mass spectrum (apci) m/z=290 (100) (M+H).

Provenance & Evidence