Potassium Phosphate, Tribasic → HCID 24825875, compound

Participants

Reaction Steps

Using the method of Example 3, Step B, 4-methylthiazol-2-amine (18.2 mL, 7.27 mmol), tert-butyl 4-(2-chloropyridin-4-yloxy)piperidine-1-carboxylate (2.50 g, 8.00 mmol), potassium phosphate (1.70 g, 8.00 mmol), tris(dibenzylideneacetone)dipalladium (0) (0.166 g, 0.182 mmol) and 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.116 g, 0.200 mmol) were reacted in toluene (20 mL) and water (5 mL), to provide tert-butyl 4-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)piperidine-1-carboxylate (1.55 g, 54.1% yield) as white solid. 1H NMR (CDCl3) δ 8.14 (d, 1H), 6.44 (d, 1H), 6.36 (bs, 2H), 4.51 (m, 1H), 3.68 (m, 2H), 3.34 (m, 2H), 2.34 (d, 3H), 1.92 (m, 2H), 1.75 (m, 2H), 1.47 (s, 9H); Mass spectrum (apci) m/z=291 (100) (M+H-Boc).

Provenance & Evidence