Potassium Phosphate, Tribasic → HCID 24825876, compound

Participants

Reaction Steps

Using the method of Example 3, Step B, 4-methylthiazol-2-amine (18.2 mL, 7.27 mmol), tert-butyl 3-(2-chloropyridin-4-yloxy)piperidine-1-carboxylate (2.50 g, 8.00 mmol), potassium phosphate (1.70 g, 8.00 mmol), tris(dibenzylideneacetone)dipalladium (0) (0.166 g, 0.182 mmol) and 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.116 g, 0.200 mmol) were reacted in toluene (20 mL) and water (5 mL) to provide tert-butyl 3-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)piperidine-1-carboxylate ((1.70 g, 53.3% yield) as yellow solid. 1H NMR (CDCl3) δ 9.01 (bs, 1H), 8.15 (d, 1H), 6.46 (dd, 1H), 6.36 (s, 2H), 4.30 (m, 1H), 2.94-3.77 (m, 3H), 2.33 (d, 3H), 2.01 (bm, 1H), 1.79 (bm, 3H), 1.52 (m, 1H), 1.39 (bs, 9H); Mass spectrum (apci) m/z=391 (100) (M+H).

Provenance & Evidence