Water → HCID 24825877, Verbindung

Beteiligte Stoffe

Reaktionsschritte

Using the method of Example 3, Step B, 4-methylthiazol-2-amine (9.20 mL, 3.68 mmol), 4-(3-(tert-butyldimethylsilyloxy)phenylthio)-2-chloropyridine (1.42 g, 4.05 mmol), potassium phosphate (0.859 g, 4.05 mmol), tris(dibenzylideneacetone)-dipalladium (0) (0.0842 g, 0.0920 mmol) and 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.0585 g, 0.101 mmol) were reacted in toluene (10 mL) and water (3 mL) to afford N-(4-(3-(tert-butyldimethylsilyloxy)phenylthio)pyridin-2-yl)-4-methylthiazol-2-amine (0.500 g, 28.5% yield) as yellow solid. 1H NMR (CDCl3) δ 8.08 (d, 1H), 7.27 (t, 1H), 7.12 (dt, 1H), 7.00 (t, 1H), 6.90 (m, 1H), 6.56 (dd, 1H), 6.47 (d, 1H), 6.32 (d, 1H), 2.23 (d, 3H), 0.96 (s, 9H), 0.18 (s, 6H).

Herkunft & Nachweise