Potassium Phosphate, Tribasic → HCID 24825880, compound

Participants

Reaction Steps

Using the method of Example 3, Step B, 4-methylthiazol-2-amine (16.77 mL, 6.708 mmol), 2-chloro-4-(5,6,7,8-tetrahydronaphthalen-1-yloxy)pyridine (1.584 g, 6.099 mmol), potassium phosphate (1.424 g, 6.708 mmol), Pd2(dba)3 (0.1396 g, 0.1525 mmol) and 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.09528 g, 0.1647 mmol) were reacted to provide N-(4-methylthiazol-2-yl)-4-(5,6,7,8-tetrahydronaphthalen-1-yloxy)pyridin-2-amine hydrochloride (1.035 g, 45.39% yield) after salt formation. 1H NMR (d6-DMSO) δ 8.23 (d, 1H), 7.24 (t, 1H), 7.09 (d, 1H), 6.96 (d, 1H), 6.69 (s, 1H), 6-65 (m, 1H), 6.54 (m, 1H), 2.79 (m, 2H), 2.48 (m, 2H), 2.25 (s, 3H), 1.70 (m, 4H); Mass spectrum (apci) m/z=338.2 (M+H—HCl).

Provenance & Evidence