Potassium Phosphate, Tribasic → HCID 24825979, compound

Participants

Reaction Steps

Using the method of Example 3, Step B, 4-chloro-6-phenoxypyrimidine (0.697 g, 3.37 mmol), 4-methylthiazol-2-amine (7.66 mL, 3.07 mmol), potassium phosphate (0.716 g, 3.37 mmol), Pd2(dba)3 (0.0702 g, 0.0766 mmol) and 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.0488 g, 0.0843 mmol) in toluene (3 mL) and water (3 mL) to afford 4-methyl-N-(6-phenoxypyrimidin-4-yl)thiazol-2-amine (0.161 g, 18.5% yield) as off white solid. 1H NMR (CDCl3), 8.56 (d, 1H), 7.43 (m, 2H), 7.28 (dt, 1H), 7.14 (m, 2H), 6.46 (d, 1H), 6.29 (s, 1H), 6.20 (m, 2H), 2.27 (d, 3H); Mass spectrum (esi) m/z=385 (100) (M+H).

Provenance & Evidence