Trifluoroacetic acid → HCID 24826059, compound

Participants

Reaction Steps

A 100 mL round bottom flask was charged with tert-butyl 4-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)piperidine-1-carboxylate (1.50 g, 3.84 mmol) in dichloromethane (10 mL) and added 2,2,2-trifluoroacetic acid (0.888 mL, 11.5 mmol). The reaction mixture was stirred at room temperature for 2 hours, then concentrated to provide 4-methyl-N-(4-(piperidin-4-yloxy)pyridin-2-yl)thiazol-2-amine TFA salt (1.6 g, 100%) as a light yellow solid. 1H NMR (DMSO) δ 8.53 (bs, 2H), 8.15 (d, 1H), 6.67 (dd, 1H), 6.61 (m, 1H), 6.56 (d, 1H), 4.74 (m, 1H), 3.25 (bm, 2H), 3.11 (bm, 2H), 2.23 (d, 3H), 2.10 (bm, 2H), 1.84 (bm, 2H); Mass spectrum (apci) m/z=291 (100) (M+H).

Provenance & Evidence