Potassium Phosphate, Tribasic → HCID 24826066, compound

Participants

Reaction Steps

Using the method of Example 3, Step B, 4-methylthiazol-2-amine (59.5 mL, 23.8 mmol), methyl 3-(2-chloropyridin-4-ylthio)benzoate (6.05 g, 21.6 mmol), potassium phosphate (5.05 g, 23.8 mmol), Pd2(dba)3 (0.495 g, 0.541 mmol) and 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.338 g, 0.584 mmol) were reacted to provide methyl 3-(2-(4-methylthiazol-2-ylamino)pyridin-4-ylthio)benzoate (5.68 g, 73.5% yield). 1H NMR (d6-DMSO) δ 11.06 (s, 1H), 8.10 (m, 3H), 7.87 (m, 1H), 7.70 (t, 1H), 6.72 (s, 1H), 6.64 (dd, 1H), 6.53 (s, 1H), 3.88 (s, 1H), 2.19 (s, 3H); Mass spectrum (apci) m/z=358.1 (M+H).

Provenance & Evidence