Triethylamine → HCID 24826149, compound

Participants

Reaction Steps

Using the method of Example 32, 2-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)benzoic acid (0.100 g, 0.3055 mmol), triethylamine (0.2129 mL, 1.527 mmol), ethyl chloroformate (0.03213 mL, 0.3360 mmol), N-isopropyl-ethylenediamine (0.1143 mL, 0.9164 mmol) in THF (2 mL) were reacted to provide N-(2-(isopropylamino)ethyl)-2-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)benzamide dihydrochloride (0.122 g, 81.62% yield) as an off white solid. 1H NMR (DMSO) δ 8.63 (bs, 1H), 8.55 (m, 1H), 8.18 (d, 1H), 7.76 (dd, 1H), 7.62 (dt, 1H), 7.42 (dt, 1H), 7.27 (d, 1H), 6.59 (s, 1H), 6.56 (m, 1H), 6.53 (m, 1H), 3.42 (m, 2H), 3.25 (m, 1H), 2.86 (m, 2H), 2.23 (d, 3H), 1.17 (d, 6H); Mass spectrum (esi) m/z=412 (100) (M+H).

Provenance & Evidence