Triethylamine → HCID 86634722, compound

Participants

Reaction Steps

Using the method of Example 32, 2-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)-benzoic acid (0.1 g, 0.3055 mmol), triethylamine (0.2129 mL, 1.527 mmol), ethyl carbonochloridate (0.03213 mL, 0.3360 mmol), 1-ethylpiperazine (0.1164 mL, 0.9164 mmol) in THF (2 mL) were reacted to provide (4-ethylpiperazin-1-yl)(2-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)phenyl)methanone dihydrochloride (0.05 g, 32.64% yield). 1H NMR (DMSO) δ 8.18 (d, 1H), 7.6859 (dt, 1H), 7.54 (d, 1H), 7.42 (t, 1H), 7.29 (d, 1H), 6.59 (m, 2H), 6.56 (m, 1H), 3.35-3.63 (m, 4H), 3.12 (m, 2H), 2.50 (m, 4H, under DMSO), 2.22 (d, 3H), 1.22 (t, 2H); Mass spectrum (esi) m/z=424(100) (M+H).

Provenance & Evidence