Triethylamine → HCID 178431957, compound

Participants

Reaction Steps

Using the method of Example 32, 2-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)benzoic acid (0.1 g, 0.3055 mmol), triethylamine (0.2129 mL, 1.527 mmol), ethyl carbonochloridate (0.03213 mL, 0.3360 mmol), and histamine (0.1019 g, 0.9164 mmol) were reacted in THF (2 mL) to provide N-(2-(1H-imidazol-4-yl)ethyl)-2-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)benzamide dihydrochloride (0.084 g, 55.17% yield). 1H NMR (CDCl3) δ 8.38 (s, 1H), 8.08 (d, 1H), 7.76 (d, 1H), 7.51 (t, 1H), 7.39 (t, 1H), 7.06 (s, 1H), 7.02 (m, 2H), 6.89 (s, 1H), 6.55 (m, 2H), 3.81 (m, 2H), 3.16 (m, 2H), 2.45 (s, 3H); Mass spectrum (esi) m/z=421 (100) (M+H).

Provenance & Evidence