Triethylamine → HCID 86634723, compound

Participants

Reaction Steps

Using the method of Example 32, 3-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)benzoic acid (0.1 g, 0.3055 mmol), triethylamine (0.2129 mL, 1.527 mmol), ethyl carbonochloridate (0.03359 mL, 0.3513 mmol), N1-isopropylethane-1,2-diamine (0.1143 mL, 0.9164 mmol) were reacted in THF (2 mL) to provide N-(2-(isopropylamino)ethyl)-3-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)benzamide dihydrochloride (0.063 g, 39.59% yield) as a light yellow solid. 1H NMR (CDCl3) δ 9.51 (bs, 1H), 8.74 (s, 1H), 8.15 (d, 1H), 7.92 (d, 1H), 7.81 (s, 1H), 7.49 (t, 1H), 7.22 (d, 1H), 6.83 (d, 1H), 6.44 (s, 1H), 3.92 (m, 2H), 3.24 (m, 2H), 3.12 (m, 1H), 2.42 (s, 3H), 1.46 (d, 6H); Mass spectrum (esi) m/z=412 (100) (M+H).

Provenance & Evidence