Potassium Phosphate, Tribasic → HCID 24826254, compound

Participants

Reaction Steps

Using the method of Example 3, Step B, 4-methylthiazol-2-amine (7.88 mL, 5.52 mmol), 2-chloro-4-(2-chlorophenylthio)pyridine (1.55 g, 6.07 mmol), potassium phosphate (1.29 g, 6.07 mmol), tris(dibenzylideneacetone)dipalladium (0) (0.126 g, 0.138 mmol) and 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.0878 g, 0.152 mmol) were reacted in toluene (8 mL) to afford 4-(2-chlorophenylthio)-N-(4-methylthiazol-2-yl)pyridin-2-amine (1.54 g, 82.8% yield) as yellow solid. 1H NMR (CDCl3) δ 8.11 (d, 1H), 7.59 (dd, 1H), 7.53 (dd, 1H), 7.38 (dt, 1H), 7.29 (dt, 1H), 6.56 (dd, 1H), 6.48 (d, 1H), 2.23 (s, 3H); Mass spectrum (esi) m/z 334 (100) (M+H).

Provenance & Evidence