Water → HCID 24826334, compound

Participants

Reaction Steps

Using the method of Example 3, Step B, 4-methylthiazol-2-amine (7.007 mL, 4.905 mmol), 2-chloro-4-(3-chlorophenylthio)pyridine (1.382 g, 5.396 mmol), potassium phosphate (1.145 g, 5.396 mmol), tris(dibenzylideneacetone)dipalladium (0) (0.1123 g, 0.1226 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.07805 g, 0.1349 mmol) were reacted in toluene (7 mL) and water (2 mL) to afford 4-(3-chlorophenylthio)-N-(4-methylthiazol-2-yl)pyridin-2-amine (1.256 g, 75.93% yield) as off white solid. 1H NMR (CDCl3) δ 8.11 (d, 1H), 7.51 (t, 1H), 7.38 (m, 2H), 7.30 (m, 1H), 6.58 (dd, 1H), 6.49 (s, 1H), 6.32 (d, 1H), 2.19 (d, 3H); Mass spectrum (esi) m/z=334 (100) (M+H).

Provenance & Evidence