Water → HCID 24826335, compound

Participants

Reaction Steps

Using the method of Example 3, Step B, 4-methylthiazol-2-amine (7.01 mL, 4.91 mmol), 2-chloro-4-(4-chlorophenylthio)pyridine (1.38 g, 5.40 mmol), potassium phosphate (1.15 g, 5.40 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.112 g, 0.123 mmol), 4,5-bis(diphenyl-phosphino)-9,9-dimethyl-9H-xanthene (0.0780 g, 0.135 mmol)were reacted in toluene (7 mL) and water (2 mL) to afford 4-(4-chlorophenylthio)-N-(4-methylthiazol-2-yl)pyridin-2-amine (0.781 g, 47.2% yield) as light yellow solid. 1H NMR (CDCl3) δ 8.09 (d, 1H), 7.45 (m, 2H), 7.38 (m, 2H), 6.57 (dd, 1H), 6.44 (s, 1H), 6.34 (d, 1H), 2.17 (d, 3H); Mass spectrum (esi) m/z=334 (100) (M+H).

Provenance & Evidence