反应详情

Using the method of Example 3, Step B, 4-methylthiazol-2-amine (0.55 g, 4.82 mmol), 2-chloro-4-(naphthalen-1-ylthio)pyridine (1.44 g, 5.30 mmol), potassium phosphate (1.12 g, 5.30 mmol), Tris(dibenzylideneacetone)dipalladium (0) (0.110 g, 0.120 mmol) and 4,5-bis(diphenyl-phosphino)-9,9-dimethyl-9H-xanthene (0.0767 g, 0.132 mmol) were reacted in toluene (12 mL) and water (4 mL) to afford N-(4-methylthiazol-2-yl)-4-(naphthalen-1-ylthio)pyridin-2-amine (0.2 g, 11% yield) as yellow solid. 1H NMR (CDCl3) δ 8.26 (m, 1H), 8.01 (m, 2H), 7.93 (m, 1H), 7.90 (dd, 1H), 7.54 (m, 3H), 6.49 (dd, 1H), 6.28 (d, 1H), 6.25 (d, 1H), 2.21 (d, 3H); Mass spectrum (esi) m/z 350 (100) (M+H).