Potassium Phosphate, Tribasic → HCID 24826337, 화합물

HRID 910957노트

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HRID 910957 반응식
[CH3:1][C:2]1[N:3]=[C:4]([NH2:7])[S:5][CH:6]=1.Cl[C:9]1[CH:14]=[C:13]([S:15][C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=[CH:18][CH:17]=2)[CH:12]=[CH:11][N:10]=1.P([O-])([O-])([O-])=O.[K+].[K+].[K+].C1(P(C2C=CC=CC=2)C2C3OC4C(=CC=CC=4P(C4C=CC=CC=4)C4C=CC=CC=4)C(C)(C)C=3C=CC=2)C=CC=CC=1>C1(C)C=CC=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].O>[CH3:1][C:2]1[N:3]=[C:4]([NH:7][C:9]2[CH:14]=[C:13]([S:15][C:16]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[CH:19]=[CH:18][CH:17]=3)[CH:12]=[CH:11][N:10]=2)[S:5][CH:6]=1

참가 물질

8

반응물 4

HCID 62657Potassium Phosphate, TribasicHCID 741432-Amino-4-methylthiazoleHCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)HCID 866347242-Chloro-4-(naphthalen-1-ylthio)pyridine

생성물 1

HCID 24826337HCID 24826337, 화합물수율 11.9%

시약·촉매·용매 3

HCID 9811564Bis(dibenzylideneacetone)palladium촉매HCID 962Water용매HCID 1140Toluene용매

실험 절차

Using the method of Example 3, Step B, 4-methylthiazol-2-amine (0.55 g, 4.82 mmol), 2-chloro-4-(naphthalen-1-ylthio)pyridine (1.44 g, 5.30 mmol), potassium phosphate (1.12 g, 5.30 mmol), Tris(dibenzylideneacetone)dipalladium (0) (0.110 g, 0.120 mmol) and 4,5-bis(diphenyl-phosphino)-9,9-dimethyl-9H-xanthene (0.0767 g, 0.132 mmol) were reacted in toluene (12 mL) and water (4 mL) to afford N-(4-methylthiazol-2-yl)-4-(naphthalen-1-ylthio)pyridin-2-amine (0.2 g, 11% yield) as yellow solid. 1H NMR (CDCl3) δ 8.26 (m, 1H), 8.01 (m, 2H), 7.93 (m, 1H), 7.90 (dd, 1H), 7.54 (m, 3H), 6.49 (dd, 1H), 6.28 (d, 1H), 6.25 (d, 1H), 2.21 (d, 3H); Mass spectrum (esi) m/z 350 (100) (M+H).

출처 및 근거

ORD 기록
ord-2318b98c99da4ac9b07a52c77b0b7dd2
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022222B2

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