Hydrochloric Acid → HCID 24826503, compound

Participants

Reaction Steps

tert-Butyl 2-(3-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)phenoxy)acetate (0.530 g, 1.28 mmol) was dissolved in dichloromethane (5 mL), and trifluoroacetic acid (5 mL) was added. The reaction mixture was stirred at room temperature for one hour, the concentrated. The TFA salt was dissolved in ether (15 mL). 1M HCl in ether (6 mL) was added, and the solids were collected by filtration, washed with hexanes and dried to afford the desired product as a white solid. 1H NMR (d6-DMSO) δ 11.85 (bs, 1H), 8.25 (d, 1H), 7.41 (t, 1H), 6.88 (d, 1H), 6.80-6.83 (m, 2H), 6.67-6.70 (m, 2H), 4.72 (s, 2H), 2.26 (s, 3H).

Provenance & Evidence