HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Phosphate, Tribasic → HCID 24826506, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | 2-Amino-4-methylthiazole | HCID 74143 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | HCID 63777947 | HCID 63777947 | — |
| Reactant | HCID 86634727 | HCID 86634727 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Product | HCID 24826506 | HCID 24826506 | 44% |
Reaction Steps
Preparation of N-(4-(2-chloro-phenoxypyridin-2-yl)-4-methylthiazol-2-amine: Using the method of Example 3, Step B, 4-methylthiazol-2-amine (0.238 g, 2.08 mmol), 2-chloro-4-(2-chlorophenoxy)pyridine (0.500 g, 2.08 mmol), potassium phosphate (0.486 g, 2.29 mmol), Pd2(dba)3 (0.095 g, 0.104 mmol), and 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.060 g, 0.104 mmol) were reacted to provide N-(4-(2-chlorophenoxy)pyridin-2-yl)-4-methylthiazol-2-amine (0.293 g, 44% yield). 1H NMR (d6-DMSO) δ 11.00 (bs, 1H), 8.18 (d, 1H), 7.68 (d, 1H), 7.49 (t, 1H), 7.36-7.40 (m, 2H), 6.47-6.53 (m, 3H), 2.20 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08022222B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-5830c73b546844199395c199533e1d9a |
| Source note | uspto-grants-2011_09 |