Potassium Phosphate, Tribasic → HCID 24826507, compound

Participants

Reaction Steps

Using the method of Example 3, Step B, 4-methylthiazol-2-amine (0.284 g, 2.48 mmol), 2-chloro-4-(2,6-difluorophenoxy)pyridine (0.600 g, 2.48 mmol), potassium phosphate (0.580 g, 2.73 mmol), Pd2(dba)3 (0.114 g, 0.124 mmol), and 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.072 g, 0.124 mmol) were reacted to provide N-(4-(2,6-difluorophenoxy)pyridin-2-yl)-4-methylthiazol-2-amine (0.312 g, 39% yield). 1H NMR (d6-DMSO) δ 11.03 (s, 1H), 8.20 (d, 1H), 7.36-7.50 (m, 3H), 6.60-6.63 (m, 2H), 6.54 (s, 1H), 2.20 (s, 3H).

Provenance & Evidence