Potassium Phosphate, Tribasic → HCID 24826508, compound

Participants

Reaction Steps

Preparation of N-(4-(2,6-dichlorophenoxypyridin-2-yl)-4-methylthiazol-2-amine: Using the method of Example 3, Step B, 4-methylthiazol-2-amine (0.291 g, 2.55 mmol), 2-chloro-4-(2,6-difluorophenoxy)pyridine (0.700 g, 2.55 mmol), potassium phosphate (0.595 g, 2.80 mmol), Pd2(dba)3 (0.117 g, 0.127 mmol), and 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.074 g, 0.127 mmol) were reacted to provide N-(4-(2,6-dichlorophenoxy)pyridin-2-yl)-4-methylthiazol-2-amine (0.450 g, 50% yield). 1H NMR (d-DMSO) δ 10.99 (s, 1H), 8.20 (d, 1H), 7.71 (d, 2H), 7.45 (t, 1H), 6.50-6.54 (m, 2H), 6.47 (s, 1H), 2.20 (s, 3H).

Provenance & Evidence