Potassium Phosphate, Tribasic → HCID 24826582, compound

Participants

Reaction Steps

Using the method of Example 3, Step B, 4-methylthiazol-2-amine (0.260 g, 2.27 mmol), 2-chloro-4-(2-isopropylphenylthio)pyridine (0.600 g, 2.27 mmol), potassium phosphate (0.531 g, 2.50 mmol), Pd2(dba)3 (0.104 g, 0.114 mmol), and 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.066 g, 0.114 mmol) were reacted to provide N-(4-(2-isopropylphenylthio)pyridin-2-yl)-4-methylthiazol-2-amine hydrochloride salt (0.301 g, 35% yield). 1H NMR (d6-DMSO) δ 11.1 (bs, 1H), 8.15 (d, 1H), 7.57-7.61 (m, 3H), 7.37 (m, 1H), 6.76 (s, 1H), 6.71-6.73 (m, 2H), 3.37 (heptet, 1H), 2.26 (s, 3H), 1.17 (d, 6H).

Provenance & Evidence