Potassium Phosphate, Tribasic → HCID 24826584, compound

Participants

Reaction Steps

Using the method of Example 3, Step B, 4-methylthiazol-2-amine (0.236 g, 2.07 mmol), 2-chloro-4-(2-(trifluoromethyl)phenylthio)pyridine (0.600 g, 2.07 mmol), potassium phosphate (0.484 g, 2.28 mmol), Pd2(dba)3 (0.095 g, 0.104 mmol), and 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.060 g, 0.104 mmol) were reacted to provide 4-methyl-N-(4-(2-(trifluoromethyl)phenylthio)pyridin-2-yl)thiazol-2-amine (0.568 g, 75% yield). 1H NMR (d6-DMSO) δ 11.06 (s, 1H), 8.10 (d, 1H), 7.99 (d, 1H), 7.76-7.83 (m, 3H), 6.66 (s, 1H), 6.59 (m, 1H), 6.52 (s, 1H), 2.19 (s, 3H).

Provenance & Evidence