Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Phosphate, Tribasic → N-(4-(2,3-dichlorophenylthio)pyridin-2-yl)-4-methylthiazol-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 반응물 | 2-Amino-4-methylthiazole | HCID 74143 | — |
| 반응물 | 2-Chloro-4-(2,3-dichlorophenylthio)pyridine | HCID 86634733 | — |
| 촉매 | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 생성물 | N-(4-(2,3-dichlorophenylthio)pyridin-2-yl)-4-methylthiazol-2-amine | HCID 24826587 | 76% |
반응 단계
Using the method of Example 3, Step B, 4-methylthiazol-2-amine (0.196 g, 1.72 mmol), 2-chloro-4-(2,3-dichlorophenylthio)pyridine (0.500 g, 1.72 mmol), potassium phosphate (0.402 g, 1.89 mmol), Pd2(dba)3 (0.079 g, 0.086 mmol), and 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.050 g, 0.086 mmol) were reacted to provide N-(4-(2,3-dichlorophenylthio)pyridin-2-yl)-4-methylthiazol-2-amine (0.480 g, 76% yield). 1H NMR (d6-DMSO) δ 11.10 (s, 1H), 8.15 (d, 1H), 7.82 (d, 1H), 7.66 (d, 1H), 7.49 (t, 1H), 6.71 (s, 1H), 6.69 (d, 1H), 6.54 (s, 1H), 2.20 (s, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08022222B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-70ae68f2145442c5bae5787ce0764bae |
| 출처 메모 | uspto-grants-2011_09 |