HRID911

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2

HCID5073

Risperidone

C23H27FN4O2

结构：O=C(O)c1cc2ccccc2c(Cc2c(O)c(C(=O)O)cc3ccccc23)c1O

HCID8546

Pamoic acid

C23H16O6

PRODUCTS

生成物

结构：Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2.O=C(O)c1cc2ccccc2c(Cc2c(O)c(C(=O)O)cc3ccccc23)c1O

HCID9832248

未命名化合物

收率 81%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A solution of 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (0.048mol) in ethanol (600ml) was added to a solution of pamoic acid (0.048mol) in N,N-dimethylformamide (400ml). The mixture was stirred for 3 hours. The resulting precipitate was filtered off by suction, washed with ethanol and dried, yielding 31 g (81%) of 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylate](1:1); mp. 269.2° C.

WORKUP

后处理

filtrationThe resulting precipitate was filtered off by suction
washwashed with ethanol
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2a631a89ec7e4caea3676f4cb6dcf4c2
来源数据集: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05723467

反应 SMILES

[F:1][C:2]1[CH:30]=[CH:29][C:5]2[C:6]([CH:9]3[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][C:17]4[C:22](=[O:23])[N:21]5[CH2:24][CH2:25][CH2:26][CH2:27][C:20]5=[N:19][C:18]=4[CH3:28])[CH2:11][CH2:10]3)=[N:7][O:8][C:4]=2[CH:3]=1.[CH:31]1[CH:32]=[CH:33][C:34]2[C:35](=[CH:37][C:38]([C:57]([OH:59])=[O:58])=[C:39]([OH:56])[C:40]=2[CH2:41][C:42]2[C:51]([OH:52])=[C:50]([C:53]([OH:55])=[O:54])[CH:49]=[C:48]3[C:43]=2[CH:44]=[CH:45][CH:46]=[CH:47]3)[CH:36]=1>C(O)C.CN(C)C=O>[CH2:41]([C:42]1[C:43]2[C:48](=[CH:47][CH:46]=[CH:45][CH:44]=2)[CH:49]=[C:50]([C:53]([OH:55])=[O:54])[C:51]=1[OH:52])[C:40]1[C:34]2[C:35](=[CH:36][CH:31]=[CH:32][CH:33]=2)[CH:37]=[C:38]([C:57]([OH:59])=[O:58])[C:39]=1[OH:56].[F:1][C:2]1[CH:30]=[CH:29][C:5]2[C:6]([CH:9]3[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][C:17]4[C:22](=[O:23])[N:21]5[CH2:24][CH2:25][CH2:26][CH2:27][C:20]5=[N:19][C:18]=4[CH3:28])[CH2:11][CH2:10]3)=[N:7][O:8][C:4]=2[CH:3]=1