Potassium Phosphate, Tribasic → HCID 24826750, compound

Participants

Reaction Steps

Using the method of Example 3, Step B, 4-methylthiazol-2-amine (0.477 g, 4.18 mmol), 2-chloro-4-(pyridin-2-ylthio)pyridine (0.930 g, 4.18 mmol), potassium phosphate (0.975 g, 4.59 mmol), Pd2(dba)3 (0.191 g, 0.209 mmol), and 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.121 g, 0.209 mmol) were reacted to provide 4-methyl-N-(4-(pyridin-2-ylthio)pyridin-2-yl)thiazol-2-amine hydrochloride (0.310 g, 44% yield). 1H NMR (d6-DMSO) δ 11.55 (bs, 1H), 8.62 (d, 1H), 8.31 (d, 1H), 7.89 (t, 1H), 7.59 (d, 1H), 7.44 (m, 1H), 7.36 (s, 1H), 7.08 (d, 1H), 6.83 (s, 1H), 2.31 (s, 3H).

Provenance & Evidence