P-Toluenesulfonylhydrazide → HCID 57898922, compound

Participants

Reaction Steps

A 25 mL round-bottomed flask is charged with (E)-methyl 3-(4-(2,6-difluorophenoxy)-6-(4-methylthiazol-2-ylamino)pyridin-3-yl)acrylate (455 mg, 1.13 mmol), 4-methylbenzenesulfonohydrazide (1050 mg, 5.64 mmol), and toluene (10 mL). The reaction mixture is heated at reflux for 12 hours, then cooled to room temperature and concentrated in vacuo. The residue is purified by silica gel (20 to 30% EtOAc in hexanes) to afford methyl 3-(4-(2,6-difluorophenoxy)-6-(4-methylthiazol-2-ylamino)pyridin-3-yl)propanoate.

Provenance & Evidence