HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Ethyl 4-chloro-3-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | 2-Amino-4-methylthiazole | HCID 74143 | — |
| Reactant | Ethyl 4-chloro-3-(2-chloropyridin-4-yloxy)benzoate | HCID 86634737 | — |
| Catalyst | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl 4-chloro-3-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)benzoate | HCID 24826662 | 89.8% |
Reaction Steps
Following the method of Example 3, Step B, ethyl 4-chloro-3-(2-chloropyridin-4-yloxy)benzoate (1.64 g, 5.26 mmol), 4-methylthiazol-2-amine (0.60 g, 5.26 mmol), potassium phosphate (1.23 g, 5.78 mmol), tris(dibenzylideneacetone)dipalladium (0) (0.241 g, 0.263 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.228 g, 0.394 mmol), water (4 mL) and toluene (13 mL) were combined to give the desired product (1.84 g, 89.8% yield) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08022222B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-017223833aa14b158fd6b4bd5e7ffc58 |
| Source note | uspto-grants-2011_09 |