Sodium Hydroxide → 4-Chloro-3-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)benzoic acid hydrochloride

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Reaction Steps

Following the method of Example 31, ethyl 4-chloro-3-(2-(4-methylthiazol-2-ylamino)pyridin-4-yloxy)benzoate (0.600 g, 1.54 mmol), ethanol (30 ml), 1M NaOH (10 mL) were combined to give the desired product (0.565 g, 89.4% yield) as a light green solid. 1H NMR (d6-DMSO) δ 8.25 (d, 1H), 7.91 (dd, 1H), 7.83 (d, 1H), 7.81 (d, 1H), 6.66 (dd, 1H), 6.64 (m, 1H), 6.61 (d, 1H), 2.23 (d, 3H).

Provenance & Evidence