Potassium Carbonate → Ethyl 3-(5-bromo-2-thioureidopyridin-4-yloxy)-4-chlorobenzoate

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Reaction Conditions

Reaction Steps

A flask was charged with ethyl 3-(2-(3-benzoylthioureido)-5-bromopyridin-4-yloxy)-4-chlorobenzoate (1.37 g, 2.56 mmol), Potassium carbonate (0.496 g, 3.59 mmol) and ethanol (50 mL). The reaction mixture was stirred at 40° C. for 6 hours and then concentrated. The crude material was purified by silica gel column chromatography eluting with 10% ethyl acetate in hexanes to give the desired product (0.61 g, 54% yield) as white solid.

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