HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 911063Generated: October 30, 2026
Sodium Hydroxide → HCID 86634776, compound
https://huagongshe.com/reaction/911063
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Benzoyl-3-(4-(benzyloxy)-5-bromopyridin-2-yl)thiourea | HCID 86634775 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86634776 | HCID 86634776 | 33.9% |
Reaction Steps
A flask was charged with 1-benzoyl-3-(4-(benzyloxy)-5-bromopyridin-2-yl)thiourea (9.8 g, 22.2 mmol) and THF (200 mL). 6N NaOH (100 mL) and NaOH (5 g) were added. The reaction was stirred at 60° C. for 3 hours, then concentrated and filtered to give the desired product (2.54 g, 33.9% yield) as off white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08022222B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-0b6e172ff48a46338ae2af8944f9d1fb |
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| Source note | uspto-grants-2011_09 |
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