Tetrahydrofuran → HCID 86634783, compound

Participants

Reaction Steps

A flask was charged with ethyl 2-(2-amino-5-bromopyridin-4-yl)acetate (2.700 g, 10.42 mmol) and THF (20 mL), and benzoyl isothiocyanate (1.546 mL, 11.46 mmol) was added. The mixture was stirred overnight at ambient temperature. The thick slurry was diluted with 50 mL of 10% ethyl acetate/hexane and filtered. The filter cake was washed with 10% ethyl acetate/hexane and dried to afford the desired product (3.75 g, 85.22%) as a pale yellow fluffy solid.

Provenance & Evidence