反应详情

(5-(2-chloropyridin-4-yloxy)-4,6-dimethylpyridin-3-yl)methanol (5.00 g, 18.9 mmol) was charged with NaOH (0.1N in H2O, 19 ml, 1.9 mmol). 3% Aqueous KMnO4 (119 ml, 22.7 mmol) was then added. The reaction stirred at room temperature overnight. The solution was diluted with dichloromethane, filtered through celite, and acidified with citric acid. The organic layer was separated and the aqueous layer was extracted with DCM. The combined organic layers were dried and concentrated to give 5-(2-chloropyridin-4-yloxy)-4,6-dimethylnicotinic acid (2.66 g, 51%).

1. filtrationfiltered through celite
2. customThe organic layer was separated
3. extractionthe aqueous layer was extracted with DCM
4. customThe combined organic layers were dried
5. concentrationconcentrated