HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 911218Generated: October 30, 2026
Boron tribromide → HCID 57656514, compound
https://huagongshe.com/reaction/911218
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 2,2,2-Trifluoro-1-(6-fluoro-1,2,4,5-tetrahydro-9-methoxy-3H-3-benzazepin-3-yl)ethanone | HCID 57656200 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 57656514 | HCID 57656514 | 99% |
Reaction Steps
Dissolve 9-fluoro-6-methoxy-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine (8.1 g, 27.7 mmol) in DCM (250 mL), cool to 0° C. and add boron tribromide (5.24 mL, 55.5 mmol). Stir at ambient temperature for 1.5 h, wash the mixture with brine, dry the organic layer over Na2SO4 and concentrate in vacuo to obtain the desired intermediate (7.6 g, 99%). MS (ES+) m/z: 278 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08022062B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-e7f073fc8a384ebfb2a772005ccf71f9 |
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| Source note | uspto-grants-2011_09 |
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