Diisopropylamine → HCID 59799081, compound

HRID 911233Notes

Reaction equation

[OH:1][C:2]1[C:12]2[CH2:11][CH2:10][N:9]([C:13](=[O:18])[C:14]([F:17])([F:16])[F:15])[CH2:8][CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.C(NC(C)C)(C)C.[I:26]N1C(=O)CCC1=O>C(Cl)Cl>[OH:1][C:2]1[C:12]2[CH2:11][CH2:10][N:9]([C:13](=[O:18])[C:14]([F:17])([F:15])[F:16])[CH2:8][CH2:7][C:6]=2[CH:5]=[CH:4][C:3]=1[I:26]

Participants

Conditions

Temperature: 15 °C

Procedure

Add 6-hydroxy-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine (1.037 g, 4.0 mmol) and diisopropylamine (60.7 mg, 0.6 mmol) to anhydrous DCM (350 mL) and stir at 10-20° C. Add slowly a solution of N-iodosuccinimide (1.035 g, 4.6 mmol) in DCM (100 mL) over a period of 3 h. Stir the reaction mixture overnight and gradually warm to ambient temperature. Quench the reaction with saturated aqueous NaHCO3, separate the organic layer, wash the organic layer with 0.1N aqueous HCl, brine, dry over Na2SO4, filter and concentrate in vacuo. Purify by chromatography on silica gel eluting with EtOAc/hexane (1:20 to 1:10) to give the desired intermediate as a white solid (1.0 g, 65%). MS (ES+) m/z: 386 (M+H)+.

Workup

stirringStir the reaction mixture overnight
temperaturegradually warm to ambient temperature
customQuench
customthe reaction with saturated aqueous NaHCO3
customseparate the organic layer
washwash the organic layer with 0.1N aqueous HCl, brine
dry with materialdry over Na2SO4
filtrationfilter
concentrationconcentrate in vacuo
customPurify by chromatography on silica gel eluting with EtOAc/hexane (1:20 to 1:10)

Sources & evidence

ORD record: ord-6a020f94b10c489bbac4210a5debe708
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08022062B2

Reaction notes

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