tert-Butyl (3-aminopropyl)carbamate → HCID 57656490, compound

HRID 911241Notes

Reaction equation

HRID 911241 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]2[CH2:6][CH2:7][N:8]([C:11](=[O:16])[C:12]([F:15])([F:14])[F:13])[CH2:9][CH2:10][C:4]=2[C:3]=1OS(C(F)(F)F)(=O)=O.[NH2:27][CH2:28][CH2:29][CH2:30][NH:31]C(=O)OC(C)(C)C>>[NH2:27][CH2:28][CH2:29][CH2:30][NH:31][C:3]1[C:4]2[CH2:10][CH2:9][N:8]([C:11](=[O:16])[C:12]([F:15])([F:14])[F:13])[CH2:7][CH2:6][C:5]=2[CH:17]=[CH:18][C:2]=1[Cl:1]

Participants

3

Reactant 2

HCID 2735700tert-Butyl (3-aminopropyl)carbamateHCID 574477477-Chloro-3-(2,2,2-trifluoroacetyl)-6-trifluoromethylsulfonyloxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Product 1

HCID 57656490HCID 57656490, compoundYield 34%

Procedure

Use a method similar to the Preparation 20, using 7-chloro-3-(2,2,2-trifluoroacetyl)-6-trifluoromethanesulfonyloxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine (600 mg, 1.41 mmol) and tert-butyl N-(3-aminopropyl)-carbamate (1.11 g, 6.34 mmol) to give the title compound (34% overall).

Workup

  1. customsimilar to the Preparation 20

Sources & evidence

ORD record
ord-fc2e38ed04064e6e9e444ef726526ca6
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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