HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 911250Generated: October 30, 2026
Trifluoroacetic acid → (2R)-1-Phenoxy-2-propanamine
https://huagongshe.com/reaction/911250
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (R)-N-Boc-1-phenoxy-2-propanamine | HCID 10586857 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2R)-1-Phenoxy-2-propanamine | HCID 5324633 | 91.1% |
Reaction Steps
Dissolve (R)-2-(tert-butoxycarbonylamino)-3-phenoxy-propane (340 mg, 1.35 mmol) in DCM (80 mL), add trifluoroacetic acid (35 mL), and stir at 0° C. for 2 h. Evaporate and purify by SCX chromatography to give the title compound as a colorless oil (186 mg, 91%). MS (ES+) m/z: 151 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08022062B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-ddad170496db43ab8c454e8464ed1a9e |
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| Source note | uspto-grants-2011_09 |
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