3-Fluorophenol → HCID 57655913, compound

HRID 911254Notes

Reaction equation

HRID 911254 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12](Br)=[CH:11][C:10]=1[F:16])(C)(C)C.[F:18][C:19]1[CH:20]=[C:21]([OH:25])[CH:22]=[CH:23][CH:24]=1>>[F:16][C:10]1[CH:11]=[C:12]([O:25][C:21]2[CH:22]=[CH:23][CH:24]=[C:19]([F:18])[CH:20]=2)[CH:13]=[CH:14][C:9]=1[CH2:8][NH2:7]

Participants

3

Reactant 2

HCID 97433-FluorophenolHCID 53432589tert-Butyl [(4-bromo-2-fluorophenyl)methyl]carbamate

Product 1

HCID 57655913HCID 57655913, compoundYield 47%

Procedure

Use a method similar to Preparation 30, using (4-bromo-2-fluorobenzyl)-carbamic acid tert-butyl ester (2.12 g, 7.0 mmol) and m-fluorophenol (1.57 g, 14 mmol) to give the title compound (468 mg, 47% overall).

Workup

  1. customsimilar to Preparation 30

Sources & evidence

ORD record
ord-51bd0c913bef4452a2de8377d125b65d
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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