Ethanamine, 2,2,2-trifluoro- → 4-aminomethyl-N-(2,2,2-trifluoroethyl)-benzamide

HRID 911291Notes

Reaction equation

HRID 911291 reaction equation
[F:1][C:2]([F:6])([F:5])[CH2:3][NH2:4].C(OC([NH:14][CH2:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](O)=[O:21])=[CH:18][CH:17]=1)=O)(C)(C)C>>[NH2:14][CH2:15][C:16]1[CH:24]=[CH:23][C:19]([C:20]([NH:4][CH2:3][C:2]([F:6])([F:5])[F:1])=[O:21])=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 8536054-(((tert-Butoxycarbonyl)amino)methyl)benzoic acid

Product 1

HCID 246898914-aminomethyl-N-(2,2,2-trifluoroethyl)-benzamideYield 94%

Procedure

Use the General Procedure 6-1, using 2,2,2-trifluoroethylamine (197 mg, 2 mmol) and 4-(tert-butoxycabonylamino-methyl)-benzoic acid, to give the title compound as a clear oil (440 mg, 94%). MS (ES+) m/z: 233 (M+H)+.

Sources & evidence

ORD record
ord-a5553cb923b440dfa1c40b5bdfb6ced8
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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