HCID 2990663, compound → HCID 57656059, compound

Participants

Reaction Steps

Dissolve 4-cyano-N-cyclohexyl-2-fluoro-benzamide (620 mg, 2.5 mmol) in 7N ammonia in methanol (150 mL) and hydrogenate at 500 psi pressure in the presence of Raney® nickel (500 mg) for 16 h at 60° C. Filter the mixture and concentrate in vacuo. Purify by SCX chromatography to give the title compound as a white solid (600 mg, 94%). MS (ES−) m/z: 251 (M−H)−.

Provenance & Evidence