HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzylamine → 5-(Aminomethyl)-pyridine-2-carboxylic acid 4-fluoro-benzylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzylamine | HCID 67326 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Lithium 5-(tert-butoxycarbonylamino-methyl)-pyridine-2-carboxylate | HCID 57656023 | — |
| Product | 5-(Aminomethyl)-pyridine-2-carboxylic acid 4-fluoro-benzylamide | HCID 57656066 | 26.3% |
Reaction Steps
Use the General Procedure 6-2, using 4-fluoro-benzylamine (551 mg, 4.4 mmol), lithium 5-(tert-butoxycarbonylamino-methyl)-pyridine-2-carboxylate (740 mg, 2.93 mmol) and DIEA (2.6 mL) as cosolvent, to give the title compound as a white solid (200 mg, 26%). MS (ES+) m/z: 260 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08022062B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-4238abacbaa5438099cf3a23e75d3598 |
| Source note | uspto-grants-2011_09 |