참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethylenediamine | HCID 3301 | — |
| 반응물 | 6-Bromo-benzo[b]thiophene | HCID 12744400 | — |
| 반응물 | HCID 178418546 | HCID 178418546 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | Benzo[b]thiophene-6-carbonitrile | HCID 21816574 | 78% |
반응 단계
Heat copper(I) cyanide (0.84 g, 9.4 mmol) and 6-bromobenzo[b]thiophene (prepared as described in WO 01/23381) (1.0 g, 4.7 mmol) at 160° C. for 13 h. Cool the mixture to 0° C., add 33% aqueous ethylenediamine (20 mL) and dilute with ether. Wash the organic mixture with brine, dry over Na2SO4 and evaporate. Purify by chromatography on silica gel eluting with EtOAc/hexane (0:1 to 1:3) to give the desired intermediate (0.58 g, 78%). GC-MS m/z: 159 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08022062B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_09 |
|---|
| ORD ID | ord-4a96621390c249b5a0be2badce3a7c69 |
|---|
| 출처 메모 | uspto-grants-2011_09 |
|---|
