反应详情

To the crude 2-(1-hydroxyethyl)-6-methylpyridine (1.6 g, 11.7 mmol) in dry DCM (15 mL) add with stirring thionyl chloride (2.0 mL, 27 mmol) and continue stirring overnight Concentrate in vacuo, azeotrope three times with dry chloroform and dry under high vacuum to provide the title compound as a tan solid (1.9 g, 85%). MS (APCI+) m/z 156 (M+H)+.

1. concentrationConcentrate in vacuo
2. customdry under high vacuum