反应详情

温度

0 °C

To a stirred solution of (R)-1-(6-methyl-pyridin-2-yl)-ethanol (175 mg, 1.28 mmol) and triethylamine (355 μl, 2.56 mmol) in DCM (5 mL) at 0° C. add methanesulfonyl chloride (148 μl, 1.92 mmol). Stir at 0° C. for 30 min and quench the reaction mixture with saturated aqueous NaHCO3 at the same temperature. Extract the mixture three times with EtOAc, dry over anhydrous Na2SO4, and concentrate in vacuo. Purify by chromatography on silica gel eluting with hexane/EtOAc (8:2) to give the title compound as a colorless oil (274 mg, 100%).

1. customquench the reaction mixture with saturated aqueous NaHCO3 at the same temperature
2. extractionExtract the mixture three times with EtOAc
3. dry with materialdry over anhydrous Na2SO4
4. concentrationconcentrate in vacuo
5. customPurify by chromatography on silica gel eluting with hexane/EtOAc (8:2)