(+/-)-3,3-Dimethyl-1-p-tolyl-butan-1-ol → 3,3-Dimethyl-1-(4-methylphenyl)butan-1-one

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of (±)-3,3-dimethyl-1-p-tolyl-butan-1-ol (2.15 g, 11.3 mmol) in hexane (30 mL) add manganese dioxide (2.94 g, 33.8 mmol) and heat the mixture overnight at 65° C. Cool to ambient temperature, filter the manganese salts, and concentrate in vacuo to give the desired intermediate as a colorless oil (2.2 g, 100%).

Provenance & Evidence